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Eva Anton,
Ph.D.
Associate Professor
UNC Neuroscience
Center,
Neurosciences Research Building
105 Mason Farm Rd, CB7250
UNC School of Medicine
Chapel Hill, NC 27599
(919) 843-6114 (office)
(919) 843-6115 (lab)
email: anton@med.unc.edu
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STATEMENT
Laminar organization of neurons in cerebral cortex is
critical for normal brain function. Two distinct cellular events guarantee
the emergence of laminar organization-- coordinated sequence of neuronal
migration, and generation of radial glial cells that supports neurogenesis
and neuronal migration. Our goal is to understand the cellular and molecular
mechanisms underlying neuronal migration and layer formation in the mammalian
cerebral cortex. Towards this goal, we are studying the following three
related questions:
- What
are the signals that regulate the establishment,
development and differentiation of radial glial cells,
a key substrate for neuronal
migration in cerebral cortex?
- What
are the signals for neuronal migration that determine
how neurons reach their appropriate positions in the
developing cerebral cortex?
- What
are the specific cell- cell adhesion related mechanisms
that determine how neurons migrate
and coalesce
into distinct layers in the developing
cerebral cortex?
   
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